Medical research involving human subjects can be risky and burdensome. Therefore, such research must be reviewed and approved by a Research Ethics Committee (REC). To guarantee the safety of the subjects, it is very important that these studies be conducted in accordance with the approved protocol. An important issue in this respect is whether studies include the requisite number of subjects based on the research question. The research question is unlikely to be answered reliably if the requisite number of subjects (...) is not met. In such cases, subjects are exposed to unnecessary risks and burdens. In this descriptive study, the authors evaluated how frequently studies are completed with the required number of subjects. Moreover, the authors identified the characteristics of research that does and does not include the required number of subjects. The results of this study show that a considerable proportion of studies (41/107) were terminated although they failed to recruit a sufficient number of subjects. Furthermore, the authors found that investigator-initiated studies have significantly (p=0.028) more problems in recruiting the requisite number of subjects than studies initiated by pharmaceutical companies. Potential solutions are discussed to reduce the number of studies that do not include a sufficient number of subjects. (shrink)

Punning on names was common in Old Comedy. Aristophanes punned on the name of Lamachus, who died at Syracuse. In the same play he made the famous joke, ‘some went to Kamarina, others to Gela, and some to Katagela’—‘an invention of the poet's from the fact that the men's officers laughed at them’.

Fueled by ever-growing amounts of (digital) data and advances in artificial intelligence, decision-making in contemporary societies is increasingly delegated to automated processes. Drawing from social science theories and from the emerging body of research about algorithmic appreciation and algorithmic perceptions, the current study explores the extent to which personal characteristics can be linked to perceptions of automated decision-making by AI, and the boundary conditions of these perceptions, namely the extent to which such perceptions differ across media, (public) health, and judicial (...) contexts. Data from a scenario-based survey experiment with a national sample (N = 958) show that people are by and large concerned about risks and have mixed opinions about fairness and usefulness of automated decision-making at a societal level, with general attitudes influenced by individual characteristics. Interestingly, decisions taken automatically by AI were often evaluated on par or even better than human experts for specific decisions. Theoretical and societal implications about these findings are discussed. (shrink)

Im September 1994 wurde in Durham das dritte Durham-Tübingen Symposium über ‘frühestes Christentum und Judentum’ abgehalten. Das Thema war diesmal ‘Paulus und das mosaische Gesetz’. In seinem zusammenfassenden Schlussreferat ‘In Search of Common Ground’ , veröffentlicht in dem Sammelband ‘Paul and the Mosaic Law’ , hat der Vorsitzende, James Dunn, in einer lakonischen Anmerkung feststellen müssen dass ‘angesichts deren Wichtigkeit in der Evangelium/Gesetzantithese, der Stelle Römer 10,4 mehr Aufmerksamkeit hätte gegeben werden müssen als es die Zeit oder der Verlauf der (...) Diskussion erlaubte’ . Man kann sich fragen ob tatsächlich nur Zeitmangel oder der Verlauf der Diskussion als Ursache der Vernachlässigung dieses wichtigen Textes anzusehen sind. Es könnte auch sein – wie von einigen englischsprachigen Teilnehmern angedeutet wurde – dass der Horizont mancher Teilnehmer etwas eingeengt war durch das reformatorische Adagium sola fide, sola scriptura, sola gratia. Jedenfalls kommt es mir vor, dass man einen Versuch wagen könne, die eigene Sicht des Paulus zu erarbeiten und sich von daher behutsamer einer Erklärung von Römer 10,4 in seinem Zusammenhang zu nähern als es jene tun die im Namen des Paulus kategorisch behaupten: ‘Christus ist das Ende des Gesetzes’. (shrink)

One of the new ways used by companies to demonstrate their social responsibility is to encourage employee volunteering, whereby employees engage in socially beneficial activities on company time, while being paid by the company. The reasoning is that it is good for employee motivation (internal effects) and good for the company reputation (external effects). This article reports an empirical investigation of the internal effects of employee volunteering conducted amongst employees of the Dutch ABN-AMRO bank. The study showed that (a) socio-demographic (...) characteristics from employee volunteers markedly differ from those of non-volunteers and community volunteers and (b) employee volunteering seems to have positive effects on attitudes and behavior towards the organization. (shrink)

Teacher discipline strategies are well documented when it comes to its effects on students and the working climate in the classroom. Although it is commonly acknowledged that for student teachers classroom management is a major concern, student teachers? use of discipline strategies is largely unknown. In this paper, we examine student teachers? beliefs in relation to their discipline strategies. Three clusters of discipline strategies are distinguished: sensitive, directive and aggressive discipline strategies. Beliefs that were taken into account are self-images on (...) control and affiliation, control orientation and anticipated student responses on control and affiliation. All participants were student teachers of a one-year teacher education programme for secondary education in the Netherlands. Student questionnaires were used to measure discipline strategies (n?=?2506). Student teachers? (n?=?104) self-images, control orientation and anticipated student responses were measured with student teacher questionnaires. Results of the multiple regression analyses showed that student teachers? sensitive and directive discipline strategies are explained best by self-images on control; aggressive discipline strategies are explained best by self-images on affiliation and by control orientation. Apart from the possible academic interest in these particular findings, results are believed to be useful in a practical sense, in particular for teacher education programmes. (shrink)

In the past few years in the Netherlands and other multi-ethnic democratic states we hear sharp political and intellectual criticism on the philosophical idea of a ‘multicultural society’. In this article, the author questions the criticism of several liberal and conservative political philosophers, who in their approach give attention to the genealogy of multiculturalism. While a liberal as Brian Barry sees multiculturalism as a regression, the conservative Roger Scruton on the other hand considers this political and intellectual phenomenon as a (...) bridge too far, a symptom of the disintegration of the modern nation. The author argues that these criticisms are forcing us to abandon a form of multiculturalism that considers ‘toleration’ as the highest principle. The ‘toleration-multiculturalist’ gets entangled in inconsistencies and moral paradoxes, as soon as he wants to determine his position towards intolerant and immodest variations of the Volksgeist, the cultural homogeneity and identity. The underlying problem in the discussion among liberals, conservatives and multiculturalists is the ontological vulnerability of cultures. This vulnerability has to do with the fact that cultures, traditions and identities are dependant on the constructive work of autonomous interpreters. Therefore a permanent dialogue with the past is necessary. While nationalists and multiculturalists are inclined to eliminate this vulnerability by fixating and immunizing the cultural and national identity, the liberals are neutralizing the cultural loyalties of people through the privatisation of identities. In contrast to these positions the author pleads for a form of democracy in which the rituals of democracy mediate the permanent dissensus about the meaning of nevertheless being a national community. (shrink)

In the past few years in the Netherlands and other multi-ethnic democratic states we hear sharp political and intellectual criticism on the philosophical idea of a ‘multicultural society’. In this article, the author questions the criticism of several liberal and conservative political philosophers, who in their approach give attention to the genealogy of multiculturalism. While a liberal as Brian Barry sees multiculturalism as a regression, the conservative Roger Scruton on the other hand considers this political and intellectual phenomenon as a (...) bridge too far, a symptom of the disintegration of the modern nation. The author argues that these criticisms are forcing us to abandon a form of multiculturalism that considers ‘toleration’ as the highest principle. The ‘toleration-multiculturalist’ gets entangled in inconsistencies and moral paradoxes, as soon as he wants to determine his position towards intolerant and immodest variations of the Volksgeist, the cultural homogeneity and identity. The underlying problem in the discussion among liberals, conservatives and multiculturalists is the ontological vulnerability of cultures. This vulnerability has to do with the fact that cultures, traditions and identities are dependant on the constructive work of autonomous interpreters. Therefore a permanent dialogue with the past is necessary. While nationalists and multiculturalists are inclined to eliminate this vulnerability by fixating and immunizing the cultural and national identity, the liberals are neutralizing the cultural loyalties of people through the privatisation of identities. In contrast to these positions the author pleads for a form of democracy in which the rituals of democracy mediate the permanent dissensus about the meaning of nevertheless being a national community. (shrink)

De geopolitieke spanningen aan het begin van de eenentwintigste eeuw hebben een nieuwe interesse in het werk van Carl Schmitt gewekt. Dat geldt ook voor zijn benadering van het vraagstuk van de relatie tussen religie en politiek. Schmitt zoekt hierbij aansluiting bij zulke uiteenlopende en incompatibele auteurs als Juan Donoso Cortes en Thomas Hobbes. Vooral recent onderzoek heeft duidelijk gemaakt dat Schmitts juridisch-politieke denken inderdaad steunt op een aantal politiek-theologische premissen. Toch moeten we de actualiteit van zijn werk vooral zoeken (...) bij zijn politiek-filosofische probleemstelling die aanhaakt bij Thomas Hobbes. Schmitt kan ons vooral leren dat de privatisering van de religies als middel voor hun politieke neutralisering haar grenzen heeft, vooral in een democratische politieke orde. (shrink)

BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

This is a dictionary of Descartes and Cartesian philosophy, primarily covering philosophy in the 17th century, with a chronology and biography of Descartes's life and times and a bibliography of primary and secondary works related to Descartes and to Cartesians.

I. The Seduction of Immanence The vocabulary of humanism—in which concepts such as “man,” “humane,” and “humanity” figure prominently—has always been contentious. The sarcasm of the nineteenth-century Catholic conservative thinker Joseph de Maistre with regard to the abstraction-tainted works of revolutionary thinkers, has become famous: “In my life I have met Frenchmen, Italians, and Russians, but Man, I solemnly declare, I have never met before; perhaps he exists, but not to my personal knowledge.”1These concepts acquire a practical, political, and even (...) polemical meaning when acted upon in the name of man, human rights, and finally humanity against “inhuman” practices…. (shrink)

There are two basic positions where tolerance as political strategy and moral viewpoint is rejected or made redundant. We are hostile to tolerance when we hold that we are defending an objective truth—religious or secular—which should also be defended and maintained by means of political and legal power. And tolerance become superfluous also when the affirmation of plurality becomes total, and tolerance identical to a vive la difference. As recent developments in my own country—the Netherlands—have demonstrated, the political outcome of (...) this last position is remarkably enough not necessarily an all-inclusive relativistic tolerance. It may just as well be one of intolerance towards ‘believers’ of all kinds, in short: tolerance becomes polemical and belligerent. Turning to religious fundamentalism or ultra-orthodoxy could then become a possible reaction to this relativistic and subjectivist position, as demonstrated in Isaac Bashevis Singer’s novel The Penitent. Between these two positions of hostility or indifference towards tolerance, we can situate that democratic attitude which may rightly be called ‘tolerance’. As ethical position, the tolerant citizen accepts the democratic disjunction between my truth and the symmetrical justice between citizens. As political strategy, a tolerant democratic regime is based upon a political act of exclusion of what I will here call ‘political fundamentalism’. (shrink)

In this contribution, the author argues that there are in our European tradition two fundamental conceptions of politics since the French Revolution. We can call them the politics as the art of co-existence, and the politics of dénouement. Both conceptions also have a very different stance towards the traditional religions: for the first one mentioned freedom of religion is constitutive, for the second one religion must serve the state or can even be made redundant. Paradigmatic in this respect was the (...) communist treatment of religion as a relic of the past that will disappear when historic reason makes our society transparant . Here politics transforms in a quasi-eschatological political religion. In the twientieth century neo-marxist philosophers say farewell to this kind of politics and begin to rediscover religious inheritances and theological motives. Today two other positions towards religions are noticeable: the utilitaristic reductionist treatment of religion as a need , and ‘Enlightment fundamentalism’ which continues the rationalist communist conception of religion as a relic of the past. The author criticises both tendencies, and defends a ‘politics without dénouement’ which correspondents to a ‘religion without guarantee’. In closing the author argues that the recent populist politics either dream of a new alliance between religion and/or ‘culture’ and the state, or – in a strange inversion of the multicultural ideals of the nineties – promote a purely polemical identity against an ‘alien’ religion, i.c. Islam. Here the author claims that both tendencies fail to recognize the real nature of the new problems. (shrink)

In this contribution, the author argues that there are in our European tradition two fundamental conceptions of politics since the French Revolution. We can call them the politics as the art of co-existence, and the politics of dénouement. Both conceptions also have a very different stance towards the traditional religions: for the first one mentioned freedom of religion is constitutive, for the second one religion must serve the state or can even be made redundant. Paradigmatic in this respect was the (...) communist treatment of religion as a relic of the past that will disappear when historic reason makes our society transparant. Here politics transforms in a quasi-eschatological political religion. In the twientieth century neo-marxist philosophers say farewell to this kind of politics and begin to rediscover religious inheritances and theological motives. Today two other positions towards religions are noticeable: the utilitaristic reductionist treatment of religion as a need, and ‘Enlightment fundamentalism’ which continues the rationalist communist conception of religion as a relic of the past. The author criticises both tendencies, and defends a ‘politics without dénouement’ which correspondents to a ‘religion without guarantee’. In closing the author argues that the recent populist politics either dream of a new alliance between religion and/or ‘culture’ and the state, or – in a strange inversion of the multicultural ideals of the nineties – promote a purely polemical identity against an ‘alien’ religion, i.c. Islam. Here the author claims that both tendencies fail to recognize the real nature of the new problems. (shrink)

The Last Judgement, heaven, hell, purgatory, the wrathful God: today, these notions seem to belong to a remote past we have - thank goodness! - left behind. The more remarkable is that, today, prisoners sometimes refer to the representation of God as Judge, as in the proposition ‘Only God can judge me’ you can find as graffito on a cell wall, or tattooed on the body of an inmate. Is this statement born from defiance of the constitutional state, from fundamentalism, (...) or from the fiction of an all-forgiving God? Nowadays, we, modern democrats, have a suspicion towards criminals and fanatics who seem to think that they can get away with an Only God can judge me. Much more common today is the reversal: not a judging God but people assuming judgement over God and over those who persist in referring to God. But the tradition of the ‘theodicee’ shows that this reversed movement of man judging God is not in the least a gesture limited to those outside the religions. In a theodicee, man summons God to appear in front of an imaginary tribunal, only for God to be defended and subsequently acquitted. As Odo Marquard argues, the modern problem of the theodicee – bringing into question God’s justice – in the end favoured atheism. Human autonomy which exonerates God by eliminating him, would imply something like an ‘atheism ad maiorem Dei gloriam’. But when humankind becomes responsible for the creation of its own history, God can no longer be summoned to any tribunal. Now only man can be summoned, and more particularly: humans which may be held accountable for the persistence of evil, responsible for our enduring discontent, obstacles of human progress or annoying remnants of the past. Here we find the beginning of the secularization of the Last Judgement. As Peter Sloterdijk argues, the vindictive God who judges and punishes at the end on times is succeeded by revolutionary groups from the nineteenth century onwards. These not only transform feelings of humiliated anger and powerlessness into those of pride and hope, but also into an effective force of revenge. In short, the theological constellation of rage and eternity has been succeeded by a political-psychological constellation of rage and history. Our representative democracy can be seen as an answer to the dangerous modern tendency to ‘tribunalising’ , because conditions of division and conflict are regarded as normal and lasting, and not as Fremdkörper or indicative of pathology. The Last Judgement becomes indefinitely suspended. However, a certain kind of ‘populism’ holds that unity and homogeneity can very well be made visible and audible’; and nowadays this seems to be accompanied by the longing to give evil, thus a form of negative transcendence, a face and parade it in front of the tribunal of the people. For prisoners, this is bad news. Against its background, the Only God can judge me may yet well up from a different source than that which I had suggested at the beginning of my argument. (shrink)

For Gianni Vattimo in his essay Belief , the widespread modern conviction that the longing for lucidity and religiosity are irreconcilable has today become questionable. In this article the author first discusses an actual instance of the philosophical yearning for lucidity, namely ‘cognitive melancholy'. This melancholia already appears in the sociologist Max Weber's diagnoses of the ‘disenchantment of the world' and of the separation of faith and kwowledge. The author sharpens somewhat further the dualism to which Weber pointed, and relates (...) it to Vattimo's attempt at softenung this dualism – of even abrogating it altogether by reconciling Christian religion with modernity. Some critical observations with regard of this attempt evoke the question of whether philosophical lucidity should not be pursued further than Vattimo does. In consequence of this the radical thrust of the Christian religion to which Vattimo claims to be returning can be percieved more clearly. (shrink)

In the Netherlands, the traditional and famous ‘culture of tolerance’ in the past few years surprisingly became associated with the laxity, half-heartedness, even negligence and indifference with regard to serious problems in a multi-ethnic society. For the time being, a polemical use of the term dominates: tolerance as an aspect of our western ‘superiority’ against barbaric fundamentalism. To regain some grip on the – at least in the Netherlands – apparently ‘hollow’, even politically and morally dubious concept of tolerance, the (...) author returns to the genealogical ‘founding forge’ of the term, the civil war fought in the name of religion in sixteenth- and seventeenth-century Europe. He demonstrates that tolerance was a key-category in a tiring, centuries-old process during which a ‘Gordian knot’ – the congruence of political power and religious faith – was being abandoned. The historical case-study of the dissident preacher John Bunyan and the early Quakers in seventeenth-century England shows, that during the Age of religious Discord political, social and religious themes are inseparably intertwined, not only from the point of view of the defenders of the status quo, but also from the standpoint of the religious dissidents and their ‘illegal’ preaching. In the intellectual history one can witness the birth of the early-modern concept of a minimal, political concept of tolerance. In a negative sense, this was a departure from attempts to uphold or restore the unity of ‘true faith’ by political coercion. In a positive sense it implied the sufferance of dissident faith and religious practices by a political power ‘in order to prevent the worse from happening’. In this process, political power became more and more an autonomous institution, above society. This minimal, political concept of tolerance has been surpassed by the state-sanctioned, juridical freedom of religion. This implies the democratic disjunction of truth and justice, that is, the recognition of an equal, reciprocal right of everyone to live and articulate his or her own truth. This legislation must be supported by a civic and social culture in which tolerance as an ethical virtue is being practiced and cherished. The most exacting form of tolerance is an attitude which tries to overcome the democratic disjunction of truth and justice, in the direction of an ‘oikoumene of religions’ or a ‘fusion of horizons’. But this subtle attitude can easily slip into an ‘idolatry of difference’ and a laissez faire-tolerance, as seemed to have happened in the Netherlands. In the final parts of this introductory essay the author presents the four articles in this thematic edition of Bijdragen: studies on Cusanus, Spinoza and Leibniz regarding tolerance, and an essay on the problems of dealing with alterity. The author concludes with the contemporary dilemma of tolerance. Should the future form of tolerance be based on universalism accompanied with the political neutralization and privatization of religion, nation, culture? Or should tolerance in a globalizing world be fed from particular traditions and sources? (shrink)

In the Netherlands, the traditional and famous ‘culture of tolerance’ in the past few years surprisingly became associated with the laxity, half-heartedness, even negligence and indifference with regard to serious problems in a multi-ethnic society. For the time being, a polemical use of the term dominates: tolerance as an aspect of our western ‘superiority’ against barbaric fundamentalism. To regain some grip on the – at least in the Netherlands – apparently ‘hollow’, even politically and morally dubious concept of tolerance, the (...) author returns to the genealogical ‘founding forge’ of the term, the civil war fought in the name of religion in sixteenth- and seventeenth-century Europe. He demonstrates that tolerance was a key-category in a tiring, centuries-old process during which a ‘Gordian knot’ – the congruence of political power and religious faith – was being abandoned. The historical case-study of the dissident preacher John Bunyan and the early Quakers in seventeenth-century England shows, that during the Age of religious Discord political, social and religious themes are inseparably intertwined, not only from the point of view of the defenders of the status quo, but also from the standpoint of the religious dissidents and their ‘illegal’ preaching. In the intellectual history one can witness the birth of the early-modern concept of a minimal, political concept of tolerance. In a negative sense, this was a departure from attempts to uphold or restore the unity of ‘true faith’ by political coercion. In a positive sense it implied the sufferance of dissident faith and religious practices by a political power ‘in order to prevent the worse from happening’. In this process, political power became more and more an autonomous institution, above society. This minimal, political concept of tolerance has been surpassed by the state-sanctioned, juridical freedom of religion. This implies the democratic disjunction of truth and justice, that is, the recognition of an equal, reciprocal right of everyone to live and articulate his or her own truth. This legislation must be supported by a civic and social culture in which tolerance as an ethical virtue is being practiced and cherished. The most exacting form of tolerance is an attitude which tries to overcome the democratic disjunction of truth and justice, in the direction of an ‘oikoumene of religions’ or a ‘fusion of horizons’. But this subtle attitude can easily slip into an ‘idolatry of difference’ and a laissez faire-tolerance, as seemed to have happened in the Netherlands. In the final parts of this introductory essay the author presents the four articles in this thematic edition of Bijdragen: studies on Cusanus, Spinoza and Leibniz regarding tolerance, and an essay on the problems of dealing with alterity. The author concludes with the contemporary dilemma of tolerance. Should the future form of tolerance be based on universalism accompanied with the political neutralization and privatization of religion, nation, culture? Or should tolerance in a globalizing world be fed from particular traditions and sources? (shrink)

Whereas the concept of ‘tolerance’ was a marginal category from the end of the sixteenth century, it has become a political key concept today. Have we not all become strangers and foreigners? As such the concept of ‘strangeness’ has lost its relevance. In recent times we witness a new turn in the dialectics of tolerance. It becomes a political and polemical category allowing for a distinct segregation between ‘them’ and ‘we’. The concept explains ‘why we are civilized and they are (...) barbarian’ . Therefore we must ask ourselves how tolerance can be saved. (shrink)

The A to Z of Descartes and Cartesian Philosophy includes a chronology, an introduction, a bibliography, and cross-reference dictionary entries Descartes's writings, concepts, and findings, as well as entries on those who supported him, those who criticized him, those who corrected him, and those who together formed one of the major movements in philosophy, Cartesianism.